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DUT Full-Length ORF: Human Gene GFP Lentivirus
Gene ID: 1854
Synonym(s): BMFDMS, dUTPase
Description: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].This ORF sequence encodes a protein that is exactly the same as the protein of NM_001948.
Catalog Number | Product | Size | Price | Qty |
---|---|---|---|---|
ET-105066-LVG-50
|
DUT Lentivirus Particles (BlastR, GFP)
|
2x25 ul per vial, 1x10^8 TU/ml |
Price:
$700.00
|
|
ET-105066-LVG-200
|
DUT Lentivirus Particles (BlastR, GFP)
|
8x25 ul per vial, 1x10^8 TU/ml |
Price:
$1,200.00
|
|
ET-105066-LVG-pd
|
DUT Lentiviral Transfer Vector (BlastR, GFP): Glycerol stock
|
1 vial |
Price:
$1,200.00
|