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ANG Full-Length ORF: Human Gene Retrovirus
Gene ID: 283
Synonym(s): ALS9, HEL168, RAA1, RNASE4, RNASE5
Description: The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020].This ORF sequence encodes a protein that is exactly the same as the proteins of NM_001145, NM_001097577, NM_001385274, NM_001385271, NM_001385273, NM_001385272. The protein has 2 functional sites and/or regions.
Catalog Number | Product | Size | Price | Qty |
---|---|---|---|---|
ET-101621-RV-50
|
ANG Retrovirus Particles (MSCV, PuroR)
|
2x25 ul per vial, 1x10^8 TU/ml |
Price:
$700.00
|
|
ET-101621-RV-200
|
ANG Retrovirus Particles (MSCV, PuroR)
|
8x25 ul per vial, 1x10^8 TU/ml |
Price:
$1,200.00
|
|
ET-101621-RV-pd
|
ANG Retrovirus Transfer Vector (MSCV, PuroR): Glycerol Stock
|
1 vial |
Price:
$1,200.00
|